DESIGN A NON-INVASIVE BLOOD GLUCOSE MONITOR USING INFRARED SPECTRUM

Authors

  • Pinku Pal Research Scholar, Department of Physics, Mansarovar Global University, Village Gadia and Ratnakhedi, Bilkisganj, Sehore, Madhya Pradesh, India
  • Supriya Bhowmik Department of Computer Science and Nutrition, Raja Narendra Lal Khan Women’s College (Autonomous), Midnapore, West Bengal, India
  • Shrabanti Pyne Department of Computer Science and Nutrition, Raja Narendra Lal Khan Women’s College (Autonomous), Midnapore, West Bengal, India
  • Deblina Giri Department of Computer Science and Nutrition, Raja Narendra Lal Khan Women’s College (Autonomous), Midnapore, West Bengal, India
  • Sanjay Das Assistant Professor, Department of Nutrition, Belda College, Belda, Paschim Medinipur, West Bengal, India
  • Koushik Das Assistant Professor, Department of Nutrition, Belda College, Belda, Paschim Medinipur, West Bengal, India
  • Satish Kumar Dept. of Physics, Faculty of Science, Mansarovar Global University, Village Gadia and Ratnakhedi, Bilkisganj, Sehore, Madhya Pradesh, India

Keywords:

T2DM, Blood Glucose, Glucometer, Infrared, Hyperglycemia, Non-Invasive

Abstract

The incidence of Type 2 Diabetes mellitus (T2DM) is progressively escalating, and the increasing susceptibility to this ailment in India underscores the considerable health obstacle it presents to individuals and families in the country. According to International Diabetic Federation, 537 million adults are currently living with diabetes, and this will further increase to more than 700 million by 2045. T2DM is not cured, it can only be controlled with medication and/or insulin therapy. T2DM patients regularly monitor their blood glucose by glucometer, which is invasive and painful method, required blood sample and also it is cost effective for low-income group of family. In this context, our study was aimed to design a non-invasive blood glucose measuring instrument. Blood glucose monitoring was divided into invasive and non-invasive method of 10 nondiabetic persons and 10 diabetic persons. In invasive blood glucose measurement was done by glucometer and also HbA1c measured by semi-auto analyzer. Non-invasive blood glucose monitoring was performed using our own designed non-invasive glucometer using infrared (IR) of 960 nm wave length, photo diode, operational amplifier (OPAMP), and light-emitting diode (LED). From the invasive method mean blood glucose and HbA1c for nondiabetic persons are 96.20±1.24, 4.86±0.12 and for diabetic persons are 225.20±2.75, 9.41±0.38 respectively. Our own designed non-invasive glucose sensor identified only hypo and hyperglycemia when IR passed through fingertip. It has been concluded that non-invasive blood glucose sensor sensed here only qualitative manner but required more specified for quantitative measurement.   

References

I. Aljunid SM, Aung YN, Ismail A, Abdul Rashid SA, Nur AM, Cheah J, et al. Economic burden of hypoglycemia for type II diabetes mellitus patients in Malaysia. PLoS One. 2019;14(10): e0211248. doi: 10.1371/journal.pone.0211248.

II. Butt MD, Ong SC, Wahab MU, Rasool MF, Saleem F, Hashmi A, et al. Cost of illness analysis of type 2 diabetes mellitus: the findings from a lower-middle income country. International Journal of Environmental Research and Public Health. 2022;19(19):12611. doi: 10.3390/ijerph191912611.

III. Sefah IA, Okotah A, Afriyie DK, Amponsah SK. Adherence to oral hypoglycemic drugs among type 2 diabetic patients in a resource-poor setting. International Journal of Applied and Basic Medical Research. 2020 ;10(2):102-9. DOI: 10.4103/ijabmr.IJABMR_270_19.

IV. Pal P, Bhowmik S, Pyne S, Mandal M, Das K, Kumar S. The socio-economic burden of expenditure for diabetes mellitus treatment: A cross sectional study. International Journal of Science and Research Archive. 2022;7(1):427-33. dio: 10.30574/ijsra.2022.7.1.0204.

V. Ganasegeran K, Hor CP, Jamil MF, Loh HC, Noor JM, Hamid Naet et al. A systematic review of the economic burden of type 2 diabetes in Malaysia. International journal of environmental research and public health. 2020 ;17(16):5723. doi: 10.3390/ijerph17165723.

VI. Gamessa TW, Suman D, Tadesse ZK. Blood glucose monitoring techniques: recent advances, challenges and future perspectives. International Journal of Advanced Technology and Engineering Exploration. 2018 ;5(46):335-44. doi:10.19101/IJATEE.2018.546008.

VII. Demitri N, Zoubir AM. Measuring blood glucose concentrations in photometric glucometers requiring very small sample volumes. IEEE Transactions on Biomedical Engineering. 2016;64(1):28-39. doi: 10.1109/TBME.2016.2530021. Epub2016.

VIII. Alsunaidi B, Althobaiti M, Tamal M, Albaker W, Al-Naib I. A review of non-invasive optical systems for continuous blood glucose monitoring. Sensors. 2021;21(20):6820. doi: 10.3390/s21206820.

IX. Shichiri M, Asakawa N, Yamasaki Y, Kawamori R, Abe H. Telemetry glucose monitoring device with needle-type glucose sensor: a useful tool for blood glucose monitoring in diabetic individuals. Diabetes Care. 1986;9(3):298-301.doi.org/10.2337/diacare.9.3.298.

X. Mujawar TH, Kasbe MS, Mule SS, Deshmukh LP. Development of wireless gas sensing system for home safety. International Journal of Engineering Sciences & Emerging Technologies. 2016;8:213-21. https://www.researchgate.net/publication/299847299_MICROCONTROLLER_BASED_BLOOD_GLUCOSE_METER_DESIGN_AND_DEVELOPMENT.

XI. Valero M, Pola P, Falaiye O, Ingram KH, Zhao L, Shahriar H, et al. Development of a noninvasive blood glucose monitoring system prototype: Pilot study. JMIR formative research. 2022 ;6(8):e38664.doi: 10.2196/38664.

XII. Bhowmick S, Giri D, Mandal M, Pyne S, Pal P, Das S, et al. Protective Effect of Arjunakwatha and Arjunasheeta in Paracetamol-induced Kidney Injury in Rat Model. International Journal of Pharmaceutical Investigation. 2023 1(1).doi: https://doi.org/10.5530/223097131728.

XIII. Pal P, Bhowmik S, Pyne S, Mandal M, Das K, Kumar S. The socio-economic burden of expenditure for diabetes mellitus treatment: A cross sectional study. International Journal of Science and Research Archive. 2022;7(1): 427-33.doi: 10.26420/intjnutrsci.2021.1060.

XIV. Baghelani M, Abbasi Z, Daneshmand M, Light PE. Non-invasive continuous-time glucose monitoring system using a chipless printable sensor based on split ring microwave resonators. Scientific Reports. 2020 ;10(1):12980. doi.org/10.1038/s41598-020-69547-1.

XV. Smyth BJ, Polaski RS, Safer A, Boettcher FA, Konrad-Martin D, Gratton MA. Point-of-Care Glucose and Lipid Profile Measures Using a Human Point-of-Care Device in Mouse Models of Type 2 Diabetes Mellitus, Aging, and Alzheimer Disease. Journal of the American Association for Laboratory Animal Science. 2021 ;60(6): 609-15.doi:10.30802/AALAS-JAALAS-21-000011

XVI. Yao J, Wang H, Yan J, Shao D, Sun Q, Yin X. Understanding the profiles of blood glucose monitoring among patients with type 2 diabetes mellitus: a cross-sectional study in Shandong, China. Patient preference and adherence. 2021:399-409. doi: 10.2147/PPA.S292086.

XVII. Chouhan S, Kallianpur S, Prabhu KT, Tijare M, Kasetty S, Gupta S. Candidal prevalence in diabetics and its species identification. International Journal of Applied and Basic Medical Research. 2019 Jan 1;9(1):49-54. DOI: 10.4103/ijabmr.IJABMR_259_18.

XVIII. Thomas A, Shenoy MT, Shenoy KT, George N. Glucometers for Patients with Type 2 Diabetes Mellitus: Are they helpful?. International Journal of Medical Students. 2021 ;9(2):140-4.doi.org/10.5195/ijms.2021.786.

XIX. Mahajan R. Distinguishing Viral and Bacterial Infections Made Easy Through the Food and Drug Administration Approved Technology-Assisted Diagnosis. International Journal of Applied and Basic Medical Research. 2021 ;11(4):205. DOI: 10.4103/ijabmr.ijabmr_662_21.

XX. Raghavendra GB, Bhat SG. Glucometer as a chairside device to assess blood glucose in periodontal patients. Journal of the international clinical dental research organization. 2010 ;2(3):130-5. doi: 10.4103/2231-0754.95286.

XXI. Al Zubaer A, Islam MA, Rahman MH, Hossain MA, Mondal SK. IoT Based Infrared Remote Controlled AC Fan Regulator. International Journal of Trend in Scientific Research and Development (IJTSRD). 2020 ;4(6):2456-6470. www.ijtsrd.com/papers/ijtsrd33484.pdf.

XXII. Arslan M, Kazi U, Rabb A, Saleem F. Accuracy, interferences and their prevention in using portable Gluco-meters. Isra Medical Journal. 2018 ;10(4).http://www.imj.com.pk/wp-content/uploads/2018/09/16-RA-30-12-17.pdf

XXIII. Bamgboje D, Christoulakis I, Smanis I, Chavan G, Shah R, Malekzadeh M, et al. Continuous non-invasive glucose monitoring via contact lenses: Current approaches and future perspectives. Biosensors. 2021 ;11(6):189. doi: 10.3390/bios11060189. PMID: 34207533.

XXIV. Beardsall K. Measurement of glucose levels in the newborn. Early human development. 2010 ;86(5): 263-7. doi: 10.1016/j.earlhumdev.2010.05.005. Epub2010.

XXV. Shah JH, Bhalodiya DK, Rawal AP, Nikam TS. Long-term results of transcatheter closure of large patent ductus arteriosus with severe pulmonary arterial hypertension in pediatric patients. International Journal of Applied and Basic Medical Research. 2020 ;10(1):3-7. DOI: 10.4103/ijabmr.IJABMR_192_19.

XXVI. Tang L, Chang SJ, Chen CJ, Liu JT. Non-invasive blood glucose monitoring technology: a review. Sensors. 2020 ;20(23): 6925.doi: 10.3390/s20236925.

XXVII. Nkono BL, Rouamba A, Omokolo JG, Tcheudi BT, Tigui BA, Dzeufiet PD et al. Antidiabetic and antiradical effects of garcinia kola seeds in dexamethasone-induced hyperglycemic rats. International Journal of Applied and Basic Medical Research. 2022 ;12(3):203-10. DOI: 10.4103/ijabmr.ijabmr_199_22.

XXVIII. Khan M, Agarwal M, Usman K, Mishra P. Prevalence of Self-care Practices among Type 2 Diabetes Mellitus Patients and its Effect on Glycemic Control: A Cross-sectional Study in Secondary and Tertiary Health-care Centers in Lucknow. International Journal of Applied and Basic Medical Research. 2023 ;13(4):246-54. DOI: 10.4103/ijabmr.ijabmr_212_23.

XXIX. Hina A, Saadeh W. Noninvasive blood glucose monitoring systems using near-infrared technology—a review. Sensors. 2022 ;22(13): 4855.doi: 10.3390/s22134855.

XXX. So CF, Choi KS, Wong TK, Chung JW. Recent advances in noninvasive glucose monitoring. Medical devices: evidence and research. 2012:45-52. doi: 10.2147/MDER.S28134. Epub 2012 Jun 29.

XXXI. Ismail A, Suddin LS, Sulong S, Ahmed Z, Kamaruddin NA, Sukor N. Economic burden of managing Type 2 diabetes mellitus: Analysis from a Teaching Hospital in Malaysia. Indian journal of public health. 2017;61(4):243-7. doi: 10.4103/ijph.IJPH_24_16. PMID: 29219128.

Additional Files

Published

01-09-2024

How to Cite

Pinku Pal, Supriya Bhowmik, Shrabanti Pyne, Deblina Giri, Sanjay Das, Koushik Das, & Satish Kumar. (2024). DESIGN A NON-INVASIVE BLOOD GLUCOSE MONITOR USING INFRARED SPECTRUM. International Educational Applied Scientific Research Journal, 9(9). Retrieved from https://ieasrj.com/journals/index.php/ieasrj/article/view/357