EFFICACY OF NIMBAPATRA AGADA IN CISPLATIN INDUCED HEMOTOXICITY IN MALE SWISS ALBINO MICE

Anjana M., P. A. Aboobaker, Ramadasan Kuttan

Abstract


In the ecology of Kerala, vipers dominate over all the species of poisonous snakes. Viper venom has more hemotoxic contents. Nimbapatra Agada (Neem leaf paste and milk in ratio 1:5) mentioned in viṣavaidya jyotsnika- maṇḍali viṣa sāmānya cikitsa prakaraṇa in hematemesis due to viper envenomation. Traditional viṣa vaidyās in Kerala practicing this formulation in bleeding conditions due to viper bite. Cisplatin, a potent chemotherapeutic drug causing myelosuppression
(hemotoxicity) nephrotoxicity and oxidative stress. If the efficacy of Agada proven by reverse pharmacology, it can be used in chemotherapy induced toxicity. So an experimental study has been planned to prove the efficacy of Nimbapatra Agada in Cisplatin induced Hemotoxicity.


Keywords


Viper snake venom , Cisplatin, Nimbapatra Agada, Hemotoxicity

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