Neeraj Bainsal


India is known as a “Botanical garden of the world” because of the largest producer of medicinal plants. These medicinal plants along with natural therapeutic value against various diseases, provide high-quality food and raw materials. Considerable work has been done on medicinal plants to the treatment of liver diseases, some of the plant products have been marketed as hepatoprotective drugs, based on their traditional uses and scientific reports. As the liver is considered as a vital organ, functions as a center of metabolism of nutrients such as carbohydrates, proteins and lipids and excretion of waste metabolites. Liver cell injury is due to various toxicants such as carbon tetrachloride, thioacetamide, chemotherapeutic agents, etc, and chronic alcohol consumption and microbes are well studied and reported. The available synthetic drugs to treat liver disorders in this condition also cause further damage to the liver. Hence, Herbal drugs have become increasingly popular and their use is wide-spread. Herbal medicines have been used in the treatment of liver diseases for a long time. Herbal drugs gained popularity and importance in past years because of their efficacy, safety, and cost-effectiveness.


Hepatoprotective drugs, Liver diseases, Herbal drugs, chemotherapeutic agents.

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• Agarwal SS. Development of hepatoprotective formulations from plant sources. In: Pharmacology and Therapeutics in the New MillenNium. Edited by Gupta SK, Narosa Publishing House, New Delhi, 2001, 357-358

• Saleem TSM, Chetty CM, Ramkanth S, Rajan VST, Kumar KM, Gauthaman K (2010). Hepatoprotective herbs - a review. International Journal of Research in Pharmaceutical Sciences 1: 1-5.

• Said O, Khalil K, Fulder S, Azaizeh H (2002). Ethnopharmacological survey of medicinal herbs in Israel, the Golan Heights and the West Bank region. Journal of Ethnopharmacology 83: 251-265.

• Thyagarajan SP, Jayaram S, Gopalakrishnan V, Hari R, Jeyakumar P, Sripathi MS (2002). Herbal medicines for liver diseases in India. Journal of Gastroenterology and Hepatology 17: S370-S376

• Handa SS, Sharma A, Chakraborti KK. Natural products and plants as liver protecting drugs. Fitoterapia 1986, 57(5): 307-352.

• Hwang YP, Choi JH, Jeong HG (2009). Protective effect of the Aralia continentalis root extract against carbon tetrachloride-induced hepatotoxicity in mice. Food and Chemical Toxicology 47: 75-81.

• Amat N, Upur H, Blazekovic B (2010). In vivo hepatoprotective activity of the aqueous extract of Artemisia absinthium L. against chemically and immunologically induced liver injuries in mice. Journal of Ethnopharmacology 131: 478-484.

• Yuan HD, Jin GZ, Piao GC (2010). Hepatoprotective effects of an active part from Artemisia sacrorum Ledeb. against acetaminophen-induced toxicity in mice. Journal of Ethnopharmacology 127: 528-533.

• Yanpallewar SU, Sen S, Tapas S, Kumar M, Raju SS, Acharya SB (2002). Effect of Azadirachta indica on paracetamol-induced hepatic damage in albino rats. Phytomedicine 9: 391-396.

• Wang X, Hai CX, Liang X, Yu SX, Zhang W, Li YL (2010). The protective effects of Acanthopanax senticosus Harms aqueous extracts against oxidative stress: Role of Nrf2 and antioxidant enzymes. Journal of Ethnopharmacology 127: 424-432.

• Chandan BK, Saxena AK, Shukla S, Sharma N, Gupta DK, Suri KA, Suri J,Bhadauria M, Singh B (2007). Hepatoprotective potential of Aloe barbadensis Mill. against carbon tetrachloride induced hapatotoxicity Journal of Ethnopharmacology 111: 560-566.

• Sangameswaran B, Reddy TC, Jayakar B (2008). Hepatoprotective effect of leaf extracts of Andrographis lineata Nees on liver damage caused by carbon tetrachloride in rats. Phytotherapy Research 22: 124-126.

• Fang HL, Wu JB, Lin WL, Ho HY, Lin WC (2008). Further Studies on the Hepatoprotective Effects of Anoectochilus formosanus. Phytotherapy Research 22: 291 -296.

• Ahmed B, Alam T, Varshney M, Khan SA (2002). Hepatoprotective activity of two plants belonging to the Apiaceae and the Euphorbiaceae family. Journal of Ethnopharmacology 79: 313-316.

• Bodakhe SH, Ram A (2007). Hepatoprotective properties of Bauhinia variegate bark extract. Yakugaku Zasshi 127: 1503-1507.

• Murugesh KS, Yeligar VC, Maiti BC, Maity TK (2005). Hepatoprotective and antioxidant role of Berberis tinctoria Lesch leaves on paracetamol induced hepatic damage in rate. Iranian Journal of Pharmacology and Therapeutics 4: 64-69.

• Olaleye MT, Akinmoladun AC, Ogunboye AA, Akindahunsi AA (2010). Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats. Food and Chemical Toxicology 48: 2200-2205.

• Oyejide OO, Olushola L (2005). Hepatoprotective and antioxidant properties of extracts of Armellia sinensis (black tea) in rats. African Journal of Biotechnology 4:1432-1438.

• Dhanasekaran M, Ignacimuthu S, Agastian P (2009). Potential hepatoprotective activity of ononitol monohydrate isolated from Cassia tora L. on carbon tetrachloride induced hepatotoxicity in wistar rats. Phytomedicine 16: 891-89

• Huang B, Ban X, He J, Zeng H, Zhang P, Wang Y (2010a). Hepatoprotective and antioxidant effects of the methanolic extract from Halenia elliptica. Journal of Ethnopharmacology 131: 276-281.

• Sadasivan SS, Latha PG, Sasikumar JM, Rajashekaran S, Shyamal S, Shine VJ (2006). Hepatoprotective studies on Hedyotis corymbosa (L.) Lam. Journal of Ethnopharmacology 106: 245-249.

• Amin A, Hamza AA (2005). Hepatoprotective effects of Hibiscus, Rosmarius and Salvia on azathioprine-induced toxicity in rats. Life Sciences 77: 266-278.

• Shanmugasundaram P, Venkataraman S (2006). Hepatoprotective and antioxidant effects of Hygrophila auriculata (K. Schum) Heine Acanthaceae root extract. Journal of Ethnopharmacology 104: 124-128.

• Jasemine S, Srivastava RS, Singh SK (2007). Hepatoprotective effect of crude extract and isolated lignans of Justicia simplex against CCl4-induced hepatotoxicity. Pharmaceutical Biology 45: 274-277.

• Somasundaram A, Karthikeyan R, Velmurugan V, Dhandapani B, Raja M (2010). Evaluation of hepatoprotective activity of Kyllinga nemoralis (Hutch & Dalz) rhizomes. Journal of Ethnopharmacology 127: 555-557.

• Wu YH, Zhang XM, Hu MH, Wu XM, Zhao Y (2009). Effect of Laggera alata on hepatocyte damage induced by carbon tetrachloride in vitro and in vivo. Journal of Ethnopharmacology 126: 50-56.

• Lau KM, He ZD, Dong H, Fung KP, But PPH (2002). Anti-oxidative, anti-inflammatory and hepato-protective effects of Ligustrum robustum. Journal of Ethnopharmacology 83: 63-71.

• Wills PJ, Asha VV (2006). Protective effect of Lygodium flexuosum (L.) Sw. extract against carbon tetrachloride indued acute liver injury in rats. Journal of Ethnopharmacology 108: 320-326.

• Sreedevi CD, Latha PG, Ancy P, Suja SR, Shyamal S, Shine VJ, Sini S, Anuja GI, Rajasekharan S (2009). Hepatoprotective studies on Sida acuta Burm. f. Journal of Ethnopharmacology 124: 171-175.

• Pramyothin P, Chirdchupunsare H, Rungsipipat A, Chaichantipyuth C (2005). Hepatoprotective activity of Thunbergia laurifolia Linn extract in rats treated with ethanol: In vitro and in vivo studies. Journal of Ethnopharmacology 102: 408-411.

• Sathesh Kumar S, Ravi Kumar B, Krishna Mohan G (2009). Hepatoprotective effect of Trichosanthes cucumerina Var cucumerina L. on carbon tetrachloride induced liver damage in rats. Journal of Ethnopharmacology 123: 347-350.

• Adesanoye OA, Farombi EO (2010). Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride. Experimental and Toxicologic Pathology 62: 197-206.

• Ajith TA, Hema U, Aswathy MS (2007). Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status. Food and Chemical Toxicology 45: 2267-2272.

• Dahiru D, William ET, Nadro MS (2005). Protective effect of Ziziphus mauritiana leaf extract on carbon tetrachloride induced liver injury. African Journal of Biotechnology 4: 1177-1179


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